Slay the Spire 2 characters atmosphere

Slay the Spire 2 **Potions Tier List**

Every potion ranked by burst value, boss fight potential, and overall flexibility. Know which potions to hoard and which to drink immediately.

⚠️ Slay the Spire 2 is in Early Access (launched March 2026). This tier list reflects the current build and will be updated as balance patches roll out.

METHODOLOGY

S-Tier: The best of the best. These Potions are highly sought after regardless of the situation you're in, and are worth holding on to for boss fights. A-Tier: Very powerful, but not quite as broken as those in S-Tier. These are generally worth holding until a key moment. B-Tier: Very solid options but are either not as impactful, more niche, or have a chance to whiff in certain situations. C-Tier: Your standard helpful Potion that you'll be happy to see but will rarely hold on to for long. D-Tier: Better than nothing, but they'll make you wish you had something else in a tough spot. Note: Event-exclusive potions are not included in this list.

Slay the Spire 2 Potion Tier List: Every Potion Ranked